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Objective To investigate the prefrontal lobe function in patients with bipolar disorder with impulsive aggressive behavior using magnetic resonance spectroscopy (MRS),so as to explore the possible relationship between impulsive aggressive behavior and prefrontal brain function in patients with bipolar disorder from the perspective in brain function.Methods A total of 24 patients with bipolar disorder (10 cases with impulsive aggressive behavior,and 14 with non-impulsive aggressive behavior) were enrolled in the study.The modified overt aggression behavior scale (MOAS) and the Barratt Impulsiveness Scale 11 (BIS-11) were used to evaluate the included subjects.Magnetic resonance spectroscopy (MRI) scans were performed on the subjects using 3.0T magnetic resonance imaging equipment to analyze quantitatively N-Acetyl-L-aspartic acid/Cr (NAA/Cr),choline/Cr (Cho/Cr),and glutamine and/or glutamic acid/Cr (Glx/ Cr) ratios.Results The left prefrontal NAA/Cr value in patients with bipolar disorder was significantly lower in impulsive aggressive behavior group than that in non-impulsive aggressive behavior group,and the difference was statistically significant (P ＜ 0.05);however,there was no obvious statistical difference in the comparison of the right prefrontal NAA/Cr value,as well as left and right prefrontal values of Cho/Cr and GlX/Cr between impulsive aggressive behavior group and non-impulsive aggressive behavior group.Conclusions The NAA/Cr value is significantly abnormal in the left prefrontal cortex of bipolar disorder patients with impulsive aggressive behavior (P ＜ 0.05),suggesting that there may exist decreased density of neurons in the left side of prefrontal lobe or dysfunction of neurons in bipolar disorder patients with impulsive aggressive behavior.
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Objective To explore the association between impulsively aggressive behavior and rs6922753 single nucleotide polymorphism of glutamate receptor 6 (GluR6) gene in Xinjiang Uygur and Han patients with bipolar disorder.Methods The techniques of polymerase chain reaction (PCR) and DNA sequencing technique were conducted to detect rs6922753 single nucleotide polymorphism of GluR6 gene in 240 patients with bipolar disorder.The association between the polymorphisms and impulsively aggressive behavior was analyzed with SPSS 17.0 software.Results No statistical difference was observed between the impulsively aggressive behavior group and the no impulsively aggressive behavior group of Xinjiang Han and Uygur patients with bipolar disorder in the genotype and allele frequencies for the investigated rs6922753 polymorphisms (P ＞ 0.05).Conclusions No association was found between the impulsively aggressive behavior and rs6922753 single nucleotide polymorphism of GluR6 gene in Xinjiang Uygur and Han patients with bipolar disorder.
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Objective To investigate the sleep quality of cancer patients before and after cancer so as to take effective measures to improve sleep quality of cancer patients.Methods In Xinjiang autonomous region,72 cancer patients in the Department of Oncology and Radiotherapy were surveyed for the study group and 61 benign patients as control group.The instruments including self-made general status and sleep status survey before cancer,and the Pittsburgh sleep quality index scale were used respectively.Results In the study group,40 people had sleep disorders (55.5％) before the cancer,significantly higher than control group people in 15 (24.5％),and the total Pittsburgh sleep quality index (PSQI) scores on average (14.00 ±2.39) were significantly higher than the control group (11.19 ± 2.45).The PSQI had seven sleep quality factors,with the statistical differences between two groups (P ＜ 0.05).Conclusions Chronic insomnia patients are more prone to cancer,cancer patients sleep quality is poorer,and the adjustment of the sleep disorders has more importance.Paying more attention to the regulation of cancer patients to sleep helps to improve the patient's quality of life.
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Objective To investigate the association between glutamate receptor-6 (GIuR6/GRIK2) gene polymorphism and domestic violence in Xinjiang Uygur population on alcoholics.Methods The methods of polymerase chain reaction (PCR) and DNA sequencing technique were conducted to detect rs6922753 and rs2227283 single nucleotide polymorphism of GLUR6 gene in a 104 domestic violence perpetrators on alcoholics and 80 non-domestic violence perpetrators on alcoholics.The association between the polymorphisms and violent behavior was analyzed with SPSS 17.0.Results The frequency of allele (x2 =4.935) and genotype (x2 =7.622) of rs6922753 polymorphisms in the domestic violence group were statistically different from those in the non-domestic violence group (P ＜ 0.05),there was no significant difference between two groups in allele frequencies and genotype in rs2227283 site (P ＞ 0.05).Conclusions GIuR6 gene polymorphism may be associated with domestic violence in Xinjiang Uygur population on alcoholics.
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Objective To investigate the effects of the interaction between environmental factors and monoamine oxidase A (MAOA) gene polymorphism in Han and Uygur on alcoholics in Xinjiang. Methods The data of childhood abuse and domestic aggressive behaviors were collected from 284 patients with alcohol dependence from Xinjiang using self-made questionnaires, Modified Overt Aggression Scale (MOAS) and Barratt Impulsivity Scale-11 (BIS-11). The meth?ods of PCR and DNA sequencing technique were conducted to detect rs1137070 single nucleotide polymorphism loci of MAOA gene. Logistic regression analysis was performed to adjust for interaction effects of gene and childhood abuse on domestic violence. Results The scale evaluation identified 143 patients with and 138 patients without domestic violence. Childhood abuse and gene were both risk factors in domestic violence. The interaction effect of childhood abuse with rs1137070 was significant. the relative excess risk, the interaction attribution ratio and the interaction index were 1.00,0.14 and 1.20, respectively. Conclusions The interactions between genes and environmental risk factors may contribute to the domestic violence in Han and Uygur on alcoholics in Xinjiang.
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Objective:To reduce the approval attitude to domestic violence by psychological intervention for high-risk target groups.Methods:Two districts were randomly selected from the total 5 districts in Changsha,and 93 couples with high risk of spousal violence were screened from a random sample of 317 couples.They were divided into intervention group(42 couples)and control group(51 couples).Mental health education and trainings to prevent from spousal violence were provided to the intervention group 6～7 times within 6 months,while no intervention methods were provided to the control group.After 6 months,25 couples in the intervention group and 37 couples in the control group completed the investigation and evaluation on domestic violence attitude.Results:After 6 months,the number of couples that accepted or partly accepted domestic violence was reduced(15 couples vs.25 couples),also less than that of the control group( 43 couples).No significant difference was found in the control group between before and after the intervention(P>0.05).Conclusion:The psychological intervention to the newly-married couples can change their attitudes to domestic violence.
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Objective To explore the correlation between domestic violence in pregnancy and plasma glutamate(Glu),γ-aminobutyric acid(GABA)and coaisol levels in neonatels.Methods By crosssectional survey and domestic violence(DV)interview with Abuse Assessment Survey(AAS),56 abused pregnant women were screened and 107 non-abused pregnant women served as controls.Blood from umbilical vein of neonatal were collected immediately after delivery.Levels of Glu,GABA in plasma were assayed by using high performance liquid chromatography with electrochemical detection on samples.Levels of plasma cortisol were detecteded by with immunoradiometric assay.All variables of the two groups were compared.Chi-square,t/z-test,Spearman correlation,liner regression analysis were adopted.Results In the DV group,there were 49 women(87.5%)experiencing psychological abuse and 2(3.6%)physical abuse during pregnancy.Moreover,29 women(51.8%)experienced sexual abuse in the period of prognancy.By comparison,our study showed higher levels of plasma Glu,GABA and cortisol in neonates of the DV group than those of the controls[(1509±339)pmol/L vs(811±270)pmol/L,(1460±369)pmol/L vs (707±296)pmol/L,(491±87)μg/L vs(392±108)μg/L,t=14.326,t=14.138,t=5.916,P＜0.001]. Spearman correlation analysis showed significantly positive correlation between severity of psychological abuse and levels of Glu,GABA and cortisol(r=0.705,0.696,0.425,P＜0.01)and positive correlation between the severity of sexual abuse and levels of Glu,GABA and cortisol(r=0.471,0.424,0.274,P＜0.01).Conclusion Domestic violence in pregnancy may alter the levels of some excitatory and inhibitory amino acids and change the endocrinic function in neonatels.
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Objective: To investigate the socio-demographic and cultural factors of spousal violence(SV) in order to provide systematic basis of SV prevention.Methods: By using multistage stratified sampling methods,3087 households were selected from Chenzhou city in Hunan Province.After screening,384 households had SV.Among them 80 households were randomly selected for study,in which 80 perpetrators were not in the domestic violence(DV) group.For the non-DV group,after matching of family’s structure,96 households without violence behavior were selected,in which after matching of gender and age with perpetrators,96 normal controls were enrolled.Results: The ratio of male perpetrators(81.3%) was more than female(18.7%),but female(81.3%) was more than male(19%) victims(P
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Objective:To investigate the psychosocial characteristics of the perpetrators and the victims of spouse violence (SV).Methods:80 families with a history of SV were randomly selected from communities, and their psychosocial characteristics were compared with control group of 96 non-SV families matched for family structure. A self-designed SV questionnaire, the self-report Symptom Checklist-90 (SCL-90), Eysenck's Personality Questionnaire (EPQ), Trait Coping Style and Questionnaire (TCSQ) were used in this cross-sectional survey.Results:65 husbands and 15 wives were identified as perpetrators, correspondingly 65 wives and 15 husbands as victims. The total score and factors scores of SCL-90, EPQ-N score, and scores of subjective social support, objective support and total supports were higher in perpetrators than their counterparts in control group. Negative coping style and EPQ-P score were respectively higher and lower in perpetrators than victims of SV (29.6?8.3/29.5?7.4,t=2.127, P